发明名称 |
Inhibition of smooth muscle cell proliferation by 8-methoxypsoralen photoactivated by visible light |
摘要 |
A method for inhibiting smooth muscle cell proliferation in an injured blood vessel includes the steps of administering a photoactivatable psoralen to a patient in an amount to achieve local arterial tissue levels of psoralen suitable for light-dependent inhibition of smooth muscle cell growth, and delivering radiation in the visible wavelength range to the injured region of the blood vessel at a level sufficient for photoactivation of the psoralen. The psoralen is preferably 8-methoxypsoralen and can be delivered systemically or locally. The method of the invention can be used for preventing restenosis in a blood vessel following transluminal angioplasty. Both the psoralen and the visible light can be delivered with a laser balloon catheter having a porous balloon. The method of the invention may also be used for inhibiting proliferation of other undesired cell types in a patient's body.
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申请公布号 |
US5354774(A) |
申请公布日期 |
1994.10.11 |
申请号 |
US19920996721 |
申请日期 |
1992.12.24 |
申请人 |
YALE UNIVERSITY |
发明人 |
DECKELBAUM, LAWRENCE I.;GASPARRO, FRANCIS P.;SUMPIO, BAUER K. |
分类号 |
A61K31/365;A61K31/37;A61K41/00;(IPC1-7):A61K31/35 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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