| 摘要 |
UTRs of cell structural proteins, particularly associated with muscle, or their complementary sequences or ribozymes comprising complementary sequences ("riboregulators") are shown to be capable of regulation of cell division and/or cell differentiation. Thus by providing the sequences exogenously or providing genes which transcribe the sequences endogenously, the fate of cells can be controlled, as to division or differentiation. The sequences can be used for controlling proliferation of neoplastic cells or in gene therapy, or to treat diseases associated with defects in cellular differentiation, or to drive cells to differentiate or to divide. |
