[Aryl(alkyl)carbonyl]-heterocyclic compounds processes for preparing them and pharmaceutical compositions containing them

摘要

The invention relates to the compounds of formula (I): in which Ar: represents a phenyl or naphthyl group, Ar being unsubstituted or substituted by one or a number of radicals chosen from halogen, lower alkyl, lower alkoxy and trifluoromethyl, n: represents 0 or an integer from 1 to 4, B: represents a group or , and A: represents a group of formula (A1) or (A2): in which: E: represents a linear or branched alkylene chain containing 1 to 6 carbon atoms; R1: represents a radical chosen from hydrogen, hydroxyl, lower alkyl and lower alkoxy, R2: represents a radical chosen from hydrogen, lower alkyl and where E1 has the same definition as E as described above and where R4 and R5 are chosen, independently of one another, from hydrogen and lower alkyl or together form, with the nitrogen atom which carries them, a heterocycle chosen from pyrrolidine, piperidine, substituted piperidine, morpholine, piperazine and substituted piperazine, R3: represents a radical chosen from hydrogen and lower alkyl, and X: represents a sulphur or oxygen atom, to their optical isomers and to their addition salts with a pharmaceutically acceptable base or acid, and to their use as medicaments.