发明名称 |
Process for the synthesis of semisynthetic glycosaminoglycans containig alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3. |
摘要 |
<p>A process for the synthesis of semi-synthetic glycosaminoglycans of general formula III <CHEM> is described in which one of the saccharide units characteristic of glycosaminoglycans with heparin or heparan structure, more specifically that of alpha -L-iduronic-2-O-sulfate acid, has undergone a structural modification, entirely or in part, with transformation into alpha -L-galacturonic acid substituted in position 3 with nucleophilic radicals of general formula II <CHEM> Said process is carried out by treating glycosaminoglycans with heparin or heparan structure by means of a nucleophilic reagent in alkaline medium.</p> |
申请公布号 |
EP0618235(A1) |
申请公布日期 |
1994.10.05 |
申请号 |
EP19940104309 |
申请日期 |
1994.03.18 |
申请人 |
ALFA WASSERMANN S.P.A. |
发明人 |
UNGARELLI, FABRIZIO;PIANO, SILVANO |
分类号 |
C08B37/10;C08B37/00;(IPC1-7):C08B37/10 |
主分类号 |
C08B37/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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