发明名称 |
Morphalinomethyl-substituted 1-phenyl-indero-[1,2-c]pyrazol-3-yl derivatives of 2-cyano-3-oxo-propanamides useful in the treatment of rheumatoid arthritis |
摘要 |
This invention relates to a method of treating rheumatoid arthritis, which method comprises administering to a mammal a therapeutically effective amount of a compound of formula (I): <IMAGE> (I) wherein R1 is unsubstituted or substituted phenyl; R2 is a morpholinomethyl group; R3 is hydrogen; R4 is hydrogen or C1-C6 alkyl; Ra is hydrogen; and Rb is a group -(A)m-R5 wherein m is zero or 1, A is a C1-C6 alkylene chain and R5 is unsubstituted or substituted phenyl; or a pharmaceutically acceptable salt thereof.
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申请公布号 |
US5352676(A) |
申请公布日期 |
1994.10.04 |
申请号 |
US19930084470 |
申请日期 |
1993.07.01 |
申请人 |
FARMITALIA CARLO ERBA SRL |
发明人 |
DORIA, GIANFEDERICO;ISETTA, ANNA M.;FERRECCIO, RINALDO;FERRARI, MARIO;FORNASIERO, MARIA C.;TRIZIO, DOMENICO |
分类号 |
C07D231/54;A61K31/415;A61K31/44;A61P37/00;C07D491/048;C07D495/04;(IPC1-7):A61K31/535;A61K31/115 |
主分类号 |
C07D231/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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