发明名称 |
Isolation and structure of Halistatin 2 |
摘要 |
An intensive long-term investigation of marine organisms as sources of new anticancer drugs has led to the isolation and structural elucidation (primarily by high field NMR and mass spectrometry) of halistatin 2, a new polyether macrolide of the halipyran-type, from the Western Indian Ocean sponge Axinella cf. carteri (Dendy). Halistatin 2 (1.4x10-6% yield) caused the accumulation of cells arrested in mitosis, inhibited tubulin polymerization, and inhibited the binding of radiolabeled vinblastine and GTP to tubulino. Further, Halistatin 2 displayed significant activity against selected human tumor cell lines.
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申请公布号 |
US5352804(A) |
申请公布日期 |
1994.10.04 |
申请号 |
US19930004852 |
申请日期 |
1993.01.19 |
申请人 |
ARIZONA BOARD OF REGENTS, A BODY CORPORATE, ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY |
发明人 |
PETTIT, GEORGE R.;GAO, FENG |
分类号 |
A61K31/365;A61K35/56;A61P35/00;A61P35/02;C07D493/22;C07H9/02;C12P17/18;C12P19/44;(IPC1-7):C07D323/00 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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