发明名称 |
Process for the preparation of 5-(trifluoromethyl)-uracil, and the novel compounds 2,4-dichloro-5-trichloromethyl-pyrimidine and 2,4-difluoro-5-trifluoromethyl-pyrimidine |
摘要 |
5-Trifluoromethyl-uracil is obtained by chlorinating thymine under mild conditions, further chlorinating the resulting 2,4-dichloro-5-methyl-pyrimidine under drastic conditions to give 2,4-dichloro-5-trichloromethylpyrimidine, reacting the latter with a fluorinating agent to give 2,4-fluorinated and/or -chlorinated 5- trifluoromethylpyrimidines and subjecting these to hydrolysis. The novel chemical compounds 2,4-dichloro- 5-trichloromethylpyrimidine and 2,4-difluoro-5-trifluoromethylpyrimidine are obtained in the course of this process.
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申请公布号 |
US5352787(A) |
申请公布日期 |
1994.10.04 |
申请号 |
US19930086696 |
申请日期 |
1993.07.02 |
申请人 |
BAYER AKTIENGESELLSCHAFT |
发明人 |
ANDRES, PETER;MARHOLD, ALBRECHT |
分类号 |
C07D239/30;C07D239/54;(IPC1-7):C07D239/02 |
主分类号 |
C07D239/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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