发明名称 |
Process for the production of a novel endothelin antagonist |
摘要 |
Fermentation processes for the production of a compound of the Structural Formula I <IMAGE> I The compound of Structural Formula I has been shown to have endothelin antagonist activity and is therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure vasospasm, cerebral and cardia ischemia, myocardial infarction inflammatory diseases, Raynaud's disease, endotoxin shock and asthma.
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申请公布号 |
US5352800(A) |
申请公布日期 |
1994.10.04 |
申请号 |
US19930029745 |
申请日期 |
1993.03.11 |
申请人 |
MERCK & CO., INC. |
发明人 |
BILLS, GERARD F.;GOETZ, MICHAEL A.;GIACOBBE, ROBERT A.;HERRANZ, LUCIA;TURNER JONES, E. TRACY;PELAEZ, FERNANDO;KONG, YU L.;SINGH, SHEO B.;STEVENS-MILES, SIOBHAN |
分类号 |
C07D207/38;(IPC1-7):C07D207/273 |
主分类号 |
C07D207/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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