PROCESSES FOR THE PREPARATION OF 1,3-BIS(1,2,4-TRIAZOL-1-YL)-PROPAN-2-OL DERIVATIVES

摘要

The invention provides a regiospecific process for the preparation of 1,3-bis(1,2,4-triazol-1-yl)-propan-2-ol derivatives of the general formulas I and Ia: <IMG> I <IMG> Ia wherein: R is alkyl, cycloalkyl, aryl or aralkyl optionally substituted by one or more same or different halogen groups; and X is the anion of a strong acid; comprising reacting an oxirane acid salt of the general formula II: <IMG> II wherein R and X are as defined above; or reacting an oxirane of the general formula II': <IMG> II' wherein R and X are as defined above, under acidic conditions, with 4H-4-amino-1,2,4-triazole of the formula III: <IMG> III and optionally deaminating a compound of the formula Ia to form a compound of formula I.