DEFECTIVE MUTANT NON-RETROVIRAL VIRUS (E.G. HSV) AS VACCINE
摘要
The application provides a pharmaceutical which comprises a mutant non-retroviral virus (particularly HSV-1 and/or HSV-2) whose genome is defective in respect of a gene essential for the production of infectious virus. The virus can infect normal cells and undergo replication and expression of viral antigen genes in those cells but cannot produce normal infectious virus. The pharmaceutical is for prophylactic or therapeutic use in generating an immune response in a subject infected therewith. Where the non-retroviral virus is a herpes simplex virus e.g. HSV-1 or HSV-2, the defect can be in the glycoprotein gH gene. Vaccines and therapeutic pharmaceuticals are provided especially for epithelial, oral, vaginal and nasal administration. Also provided is use of a mutant based on HSV-1 for the preparation of a pharmaceutical for prophylactic or therapeutic use in generating an immune response in a subject against type-2 HSV infection.
申请公布号
WO9421807(A2)
申请公布日期
1994.09.29
申请号
WO1994GB00572
申请日期
1994.03.21
申请人
CANTAB PHARMACEUTICALS RESEARCH LIMITED;INGLIS, STEPHEN, CHARLES;BOURSNELL, MICHAEL, EDWARD, GRIFFITH;MINSON, ANTHONY, CHARLES
发明人
INGLIS, STEPHEN, CHARLES;BOURSNELL, MICHAEL, EDWARD, GRIFFITH;MINSON, ANTHONY, CHARLES