发明名称 |
SYSTEM FOR CONTROLLED RELEASE OF ANTIARRHYTHMIC AGENTS |
摘要 |
A system for controlled release, site-specific delivery of therapeutic agents, particularly myocardial agents such as antiarrhythmic agents, comprises a biocompatible polymeric patch (30) with an incorporated therapeutic agent for direct placement at the epicardium of heart (31). The dosage form is fabricated so as to tailor the release characteristics as required by the nature of the physical condition desired to be treated. In a specific illustrative embodiment, ibutilide, a potent, but toxic, Class III antiarrhythmic agent, is incorporated in polyurethane and solvent-cast to form a monolithic drug delivery device which can be co-implanted with an implantable cardiac defibrillator. Advantageously, very low doses of ibutilide administered directly to the epicardium in this manner produces a reduction in defibrillation threshold. |
申请公布号 |
WO9421237(A1) |
申请公布日期 |
1994.09.29 |
申请号 |
WO1994US02838 |
申请日期 |
1994.03.15 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN;LEVY, ROBERT, J.;SINTOV, AMNON |
发明人 |
LEVY, ROBERT, J.;SINTOV, AMNON |
分类号 |
A61N1/36;A61K9/00;A61K9/22;A61L31/16;A61N1/362;A61N1/39;A61P9/06;(IPC1-7):A61K9/22;A61B17/36 |
主分类号 |
A61N1/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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