N-ACYL-DEMETHYLCOLCHICINE DERIVATIVES AND THEIR USE AS MAMMALIAN DNA TOPOISOMERASE II INHIBITORS

摘要

A novel antiproliferative drug and methods are disclosed. The drug has general structural formula (I) or (II) where R1=OR1', SR1', or NR1'R1', where R1' and R1' are the same or different and are H or lower alkyl groups, and R2 is an aroylamino group. The compound is useful for inhibiting cell proliferation in drug-resistant tumor cells.