USE OF BACTERICIDAL/PERMEABILITY INCREASING PROTEIN AND LIPOPOLYSACCHARIDE BINDING PROTEIN LEVELS AND RATIOS THEREOF IN DIAGNOSIS

摘要

Methods are provided for diagnosing and predicting the outcome of an inflammatory disorder in a subject, which comprises obtaining a bodily fluid sample from the patient, quantitatively determining the amount of BPI in the sample, comparing the amount of BPI Present in the sample with levels of BPI in samples obtained from normal subjects and with levels of BPI in samples obtained from individuals suffering from an inflammatory disorder in order to diagnose and predict the outcome of an inflammatory disorder in the subject. In addition, methods are provided for diagnosing and predicting the outcome of an inflammatory disorder in a subject, which comprises obtaining a bodily fluid sample from the subject, quantitatively determining the amount of BPI and LBP in the sample, determining the ratio of BPI to LBP in the sample, and then comparing the resulting ratio of BPI to LBP with BPI:LBP ratios obtained from normal subjects and from individuals suffering from an inflammatory disorder in order to diagnose and predict the outcome of the inflammatory disease in the subject.