发明名称 |
BROAD SPECTRUM TUMOR SUPPRESSOR GENES, GENE PRODUCTS AND METHODS FOR TUMOR SUPPRESSION GENE THERAPY |
摘要 |
The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate hostcells. The protein is a second in-frame AUG codon-initiated retinoblasoma protein of about 94 kD relative molecular mass. The present invention also relates to methods of treating a mammal having a disease or disorder characterized by abnormal cellular proliferation, such as a tumor or cancer and methods of treating abnormally proliferating cells, such as tumor or cancer cells. Treatment is accomplished by inserting a host cell compatible p94RB expression vector or an effective amount of p94RB protein into a cell or cells in need of treatment.
|
申请公布号 |
CA2159085(A1) |
申请公布日期 |
1994.09.29 |
申请号 |
CA19942159085 |
申请日期 |
1994.03.24 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
XU, HONG-JI;XU, SHI-XUE;BENEDICT, WILLIAM F. |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K48/00;A61P35/00;C07H21/04;C07K14/47;C12N5/10;C12P21/02;(IPC1-7):C12N15/85;A61K35/12;C12N15/12;A61K9/127;A61K38/17;C07K14/435;C12N15/87 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|