发明名称 |
ANTIPSYCHOTIC INDAZOLE DERIVATIVES |
摘要 |
A class of 1H-indazole derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs.
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申请公布号 |
CA2156838(A1) |
申请公布日期 |
1994.09.29 |
申请号 |
CA19942156838 |
申请日期 |
1994.03.14 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
BAKER, RAYMOND;KULAGOWSKI, JANUSZ JOZEF;LEESON, PAUL DAVID;SMITH, ADRIAN LEONARD |
分类号 |
A61K31/495;A61P25/18;C07D231/56;C07D401/12;C07D403/12;C07D405/12;(IPC1-7):C07D403/06;C07D401/14;C07D403/14;C07D405/14;A61K31/535 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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地址 |
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