ANTISENSE MOLECULES DIRECTED AGAINST A GENE FOR THE CATALYTIC SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE

摘要

The present invention is directed to a polynucleotide of less than about 50 nucleic acid bases in length, which polynucleotide hybridizes to the gene for the catalytic subunit of phosphatidylinositol 3-kinase. The present invention is also directed to a pharmaceutical composition comprising the above polynucleotide dissolved or dispersed in a physiologically tolerable diluent. The present invention is further directed to a process for inhibiting vascular smooth muscle cell proliferation which process comprises inhibiting the expression of the catalytic subunit of phosphatidylinositol 3-kinase in vascular smooth muscle cells.