发明名称 |
EXTRUSION AND FREEZE-DRYING METHOD FOR PREPARING PARTICLES CONTAINING AN ACTIVE INGREDIENT |
摘要 |
A method for preparing particles each of which consists of a carrier forming a matrix, and at least one active ingredient uniformly distributed throughout said matrix. The method comprises extrusion and freeze-drying steps, wherein 1) (a) at least one active ingredient, (b) a physiologically acceptable hydrophilic carrier, and (c) water are uniformly mixed to give a pasty mixture with a viscosity at room temperature (15-20 DEG C) of under 1 Pa.s; 2) the resulting uniform mixture is extruded and the extrudate is broken up into moist particles; 3) the resulting particles are frozen as they fall under their own weight into an inert gas stream at a below-zero temperature; and 4) said particles are freeze-dried. |
申请公布号 |
WO9421371(A1) |
申请公布日期 |
1994.09.29 |
申请号 |
WO1994FR00281 |
申请日期 |
1994.03.15 |
申请人 |
LABORATOIRE L. LAFON;NGUYEN, THANH-TAM;JACQUOT-LEYDER, JOELLE |
发明人 |
NGUYEN, THANH-TAM;JACQUOT-LEYDER, JOELLE |
分类号 |
F26B5/06;A23P1/02;A61J3/06;A61K9/14;A61K9/16;A61K9/19;B01J2/04;B01J2/20;B29C47/00;C08J9/28;F25C1/00;(IPC1-7):B01J13/04 |
主分类号 |
F26B5/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|