| 发明名称 |
USE OF PORCINE GAL .ALPHA. (1,3) GALACTOSYL TRANSFERASE IN XENOGRAFT THERAPIES |
| 摘要 |
DNA sequences encoding a porcine Gal.alpha.(1,3) galactosyl transferase and clones containing such sequences are provided. The porcine Gal.alpha.(1,3) galactosyl transferase produces the Gal.alpha.(1,3) Gal epitope on the surfaces or porcine cells. This epitope is recognized by human anti-Gal.alpha.(1,3) Gal antibodies which are responsible for hyperacute rejection of xenotransplanted pig cells, tissues and organs. Methods of reducing such hyperacute rejection are also provided.
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| 申请公布号 |
CA2157659(A1) |
申请公布日期 |
1994.09.29 |
| 申请号 |
CA19942157659 |
申请日期 |
1994.03.15 |
| 申请人 |
AUSTIN RESEARCH INSTITUTE |
发明人 |
SANDRIN, MAURO S.;MCKENZIE, IAN F., C. |
| 分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P37/00;C07H21/04;C07K16/18;C07K16/40;C07K16/42;C12N5/10;C12N9/10;C12N15/54;C12P21/08;C12R1/91;(IPC1-7):C12N15/54;C12Q1/68 |
主分类号 |
C12N15/09 |
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