Method for the resolution of racemic mixtures.

摘要

The present invention relates to a method for the resolution of racemic mixtures of threo-alkyl-2-hydroxy-3-(4-methoxyphenyl)-3-(2-X-phenylthio)-propionates of formula 1 <CHEM> wherein R1 is an alkyl group and X is NO2, NH2 or an NH-R2 group with R2 representing an acyl group or an alkoxy carbonyl group, each optionally substituted with one or more halogen atoms, comprising subjecting said racemic mixtures to reaction with an acylation reagent in an essentially anhydrous organic medium in the presence of a lipase.