Compositions for controlled release of biologically active TGF - beta.

摘要

Ceramic and polymer based compositions which direct the controlled sustained release of TGF- beta to bone tissue and improved surgical implant devices incorporating such compositions are described. The compositions and improved surgical implant devices of the invention induce and/or enhance the process of osteogenesis in animal bone tissue thereby resulting in the formation of new mature bone, and are useful for repairing orthopaedic and periodontal bone tissue defects. Several particular embodiments are described by way of examples which illustrate the methods of manufacturing the compositions and improved surgical implants, the TGF- beta release kinetic properties of the compositions, and the efficacy of the compositions and improved surgical implant devices in animal models. In one such particular embodiment, a critical defect introduced into a rat skull is repaired using a ceramic-based TGF- beta delivery composition. <IMAGE>