发明名称 Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof
摘要 There is disclosed a stable formulation of enalapril salt of the formula I <IMAGE> I which is prepared in such manner that a compound of formula II <IMAGE> II is suspended in demineralized water and a stoichiometric amount of the corresponding sodium compound such as sodium carbonate, sodium hydrogen carbonate or sodium hydroxide is added thereto, to this enalapril sodium salt prepared in situ of the formula I <IMAGE> I formulating additives are added, the whole is homogenized and formulated.
申请公布号 US5350582(A) 申请公布日期 1994.09.27
申请号 US19920980956 申请日期 1992.11.24
申请人 KRKA, TOVARNA ZDRAVIL, P.O. 发明人 MERSLAVIC, MARJO;RAZEN, JOZICA;ROTAR, ALES
分类号 A61K9/20;A61K38/55;A61K47/02;(IPC1-7):A61K9/20 主分类号 A61K9/20
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