| 摘要 |
Compounds of the structure <IMAGE> where Ar is optionally substituted carbocyclic aryl, 5- or 6-membered heterocyclic aryl, 10-membered bicyclic heterocyclic aryl containing one or two nitrogen atoms, 9- or 10-membered heterocyclic containing one or two nitrogen atoms and optionally containing a further nitrogen or oxygen atom and one oxo or thioxo substituent, benzo[b]furyl, or benzo[b]thienyl, A1 is propynyl, methylene, or a direct link to X, X is oxy, thio, sulfonyl, or NR4, A2 is selected from <IMAGE> <IMAGE> where Y is hydrogen, halogen, or nitrile; Z is hydrogen, R1 is alkyl, and R2 is hydrogen or alkyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
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