发明名称 |
Combined anti-tumor therapy with interleukin-2 and histamine, analogs thereof or H2-receptor agonists |
摘要 |
A method of inhibiting the development of malignant tumors and the formation of metastases of malignant tumor cells in a subject carrying the comprises administering to the subject IL-2 and an agent selected from the group consisting of histamine, a histamine structural analogs having H2-receptor activities, an endogenous histamine releasing preparation, and a non-histamine derivative H2-receptor agonist; the agent and the IL-2 being administered in amounts and for a time effective to attain the desired effect. A method of increasing the anti-tumor cell effect of IL-2 in a subject comprises co-administering to the subject IL-2 and an agent such as histamine, histamine structural analogs having H2-receptor activities, endogenous histamine releasing preparations or H2-receptor agonists, the agent and the IL-2 being administered in anti-tumor effective amounts and for a period of time effective to attain the desired effect.
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申请公布号 |
US5348739(A) |
申请公布日期 |
1994.09.20 |
申请号 |
US19920843052 |
申请日期 |
1992.03.02 |
申请人 |
SUNTELLO, INC. |
发明人 |
HELLSTRAND, JAN U. K.;HERMODSSON, SVANTE H. |
分类号 |
A61K31/415;A61K38/00;A61K38/19;A61K38/20;A61K45/00;A61K45/06;A61P35/00;A61P43/00;(IPC1-7):A61K45/05;C07K3/00 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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