| 摘要 |
of the disclosure A novel heterocyclic bisphosphonic acid derivatives represented by the following general formula (I): <IMG> (I) in which, <IMG> means one of following (A) and (B): <IMG> (A) wherein a dotted line in (A) means that two adjacent atoms are bonded by a single bond or a double bond, <IMG> (B) wherein R6 and R7 may be the same or different, each represents a hydrogen atom, a lower alkyl group, a halogen atom or a hydroxyl group, R1 represents a hydrogen atom or a hydroxyl group, R2, R3, R4 and R5 may be the same or different, each represents a hydrogen atom or a lower alkyl group, "n" is 0 or 1, provided that "n" is 1 when the ring <IMG> means (A), and "R1" is a hydroxyl group when the ring <IMG> means (B), or pharmaceutically acceptable salts thereof and bone resorption inhibitors containing the compound as an active ingredient.
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