发明名称 Compositions of iodophenoxy alkylene ethers for visualization of the gastrointestinal tract
摘要 A compound of the formula: <IMAGE> wherein Z=H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, wherein thealkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C1-C25 alkyl, cycloalkyl, <IMAGE> or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR1R2)p-(CR3=CR4)mQ, or (CR1R2)p-C 3BOND C-Q; R1, R2, R3 and R4 are independently H, or lower-alkyl, optionally substituted with halo; x is 1-4; n is [1-5]1-4; m is 1-15; p is 1-20; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, these compounds are useful as X-ray contrast agents or aryl-lower alkyl.
申请公布号 US5348727(A) 申请公布日期 1994.09.20
申请号 US19930029485 申请日期 1993.03.11
申请人 STERLING WINTHROP INC. 发明人 BACON, EDWARD R.;ILLIG, CARL R.;CAULFIELD, THOMAS J.;DOUTY, BRENT D.;JOSEF, KURT A.
分类号 A61K49/04;C07C43/225;C07C43/23;C07C69/92;C07C255/54;(IPC1-7):A61B5/055;A61K31/075;C07C41/00 主分类号 A61K49/04
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