发明名称 |
ANTHRACYCLINES WITH UNUSUALLY HIGH ACTIVITY AGAINST CELLS RESISTANT TO DOXORUBICIN AND ITS ANALOGS |
摘要 |
The present disclosure details novel modified anthracyclines, the synthesis thereof, and their use in treating patients with tumors. Preferred aspects of the disclosure involve modified anthracyclines which have an O-substituted aromatic ring on their sugar moiety. Other preferred aspects of the disclosure involve synthesis steps wherein a hydroxyl group on a sugar moiety to be added is blocked with a halo-substituted alkyl group during the process of adding it to an anthracycline ring compound. |
申请公布号 |
WO9420114(A1) |
申请公布日期 |
1994.09.15 |
申请号 |
WO1994US02619 |
申请日期 |
1994.03.11 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
PRIEBE, WALDEMAR;SKIBICKI, PIOTR;PEREZ-SOLER, ROMAN |
分类号 |
C07H15/252;(IPC1-7):A61K31/70;C07H15/24;C07H1/00 |
主分类号 |
C07H15/252 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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