摘要 |
<p>Disclosed are x-ray contrast compositions for oral or retrograde examination of the GI tract comprising a polymeric material capable of forming a coating on the GI tract, said polymeric material having atoms containing polarizable electrons thereon, in combination with a divalent cation; and an x-ray contrast producing agent of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="53" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>
wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>Z = H, halo, C<Sub>1</Sub>-C<Sub>20</Sub> alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;</ListItem><ListItem>R = C<Sub>1</Sub>-C<Sub>25</Sub> alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR<Sub>1</Sub>R<Sub>2</Sub>)<Sub>p</Sub> - (CR<Sub>3</Sub> = CR<Sub>4</Sub>)<Sub>mQ</Sub>, or (CR<Sub>1</Sub> R<Sub>2</Sub>)p - C ≡ C - Q;</ListItem><ListItem>Ri, R<Sub>2</Sub>, R<Sub>3</Sub> and R<Sub>4</Sub> are independently lower-alkyl, optionally substituted with halo;</ListItem><ListItem>x is 1-3</ListItem><ListItem>y is 1-4;</ListItem><ListItem>n is 1-5;</ListItem><ListItem>m is 1-15;</ListItem><ListItem>p is 1-10; and</ListItem><!-- EPO <DP n="2"> --></UnorderedLists></p><p>Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl; in a pharmaceutically acceptable carrier and a method of its use in diagnostic radiology of the GI tract.</p> |