| 摘要 |
The present invention provides for crystalline zinc-interferon alfa-2 (IFN alpha -2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN alpha -2, crystalline calcium-IFN alpha -2, and crystalline IFN alpha -2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN alpha -2 comprising forming a soluble metal-IFN alpha -2 complex, and equilibrating the soluble metal-IFN alpha -2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN alpha -2 solution to become supersaturated and form crystalline metal-IFN alpha -2. The present invention also includes crystalline metal-alfa interferon having monoclinic, plate and needle morphologies. |
