| 摘要 |
N-(2-Sulphateoethyl)piperazine of high purity is prepared by reacting N-(2-hydroxyethyl)piperazine in a mixture of highly or more highly concentrated sulphuric acid and oleum or chlorosulphonic acid at temperatures of about 80 to about 250@C, introducing the sulphation mixture obtained into a water-miscible aliphatic alcohol, isolating the N-(2-sulphatoethyl)piperazine sulphate formed, treating the still alcohol-moist N-(2-sulphatoethyl)piperazine sulphate at temperatures of about 35 to about 90@C with a basic compound in a mixture of an alkanol (C1-C2) and water, separating off the precipitated sulphate of the basic compound employed and isolating the N-(2-sulphatoethyl)piperazine formed by addition of alkanol (C1-C2). |
