发明名称 |
Preparation of copper 2-alkoxyisobutylisonitrile complexes and 99mTc labelling of 2-alkoxyisobutylisonitrile |
摘要 |
A new method for synthesizing 2-alkoxyisobutylisonitrile is provided in which isobutylene is used as the starting material. The haloalkoxylation of isobutylene in alcohol medium gives 2-alkoxyisobutylhalide which is then converted to 2-alkoxyisobutylamine. In the basic condition, the reaction of 2-alkoxyisobutylamine with chloroform produces 2-alkoxyisobutylisonitrile. The synthesis process contains three steps by which a higher yield is achieved. 2-Alkoxyisobutylisonitrile is labelled with technetium-99m by exchange labelling of stable tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex. Tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex can be prepared by the exchange of acetonitrile molecules in tetrakis(acetonitrile)copper(I) complex with isonitrile ligands.
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申请公布号 |
US5346995(A) |
申请公布日期 |
1994.09.13 |
申请号 |
US19930003736 |
申请日期 |
1993.01.13 |
申请人 |
INSTITUTE OF NUCLEAR ENERGY RESEARCH |
发明人 |
TE-WEI, LEE;GANN, TING;CHANG-SHINN, SU;SHYH-YI, CHYI |
分类号 |
C07B59/00;C07C291/10;C07F13/00;(IPC1-7):C07F13/00 |
主分类号 |
C07B59/00 |
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