发明名称 |
VITAMIN E DERIVATIVE AND ANTIULCER AGENT CONTAINING THE SAME AS ACTIVE INGERDIENT |
摘要 |
<p>PURPOSE:To obtain a new compound having excellent antiulcer action, useful as an antiulcer agent and capable of continuously using for a long period because of extremely reduced toxicity and side effects. CONSTITUTION:A vitamin E derivative of formula I (X is H or acyl) or its salt. The compound is obtained by reacting, e.g. carnosine of formula II with a compound of the formula Z-Cl (Z is amino acid protecting group) in an alkaline solution of NaOH aqueous solution at pH 8-10 and -10 to 10 deg.C to afford carnosine having a protected amino group and reacting the resultant compound with tocopherol of formula III in the presence of a dehydration condensing agent such as thionyl chloride in a solvent such as THF at -10-30 deg.C to afford a vitamin E derivative having protected amino group and expressed by formula IV and hydrogenating the compound of formula IV at 15-50 deg.C in the presence of a catalyst such as Pd-carbon in an inert solvent.</p> |
申请公布号 |
JPH06256185(A) |
申请公布日期 |
1994.09.13 |
申请号 |
JP19930049303 |
申请日期 |
1993.03.10 |
申请人 |
KURARAY CO LTD |
发明人 |
YOSHIKAWA MASAYUKI;TAMAI HIRONOBU;TORIHARA MASAHIRO |
分类号 |
A61K31/415;A61P1/04;C07D405/12;(IPC1-7):A61K31/415 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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