DNA encoding tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders

摘要

A tissue factor protein mutant capable of neutralizing the ability of endogenous tissue factor to induce coagulation is provided. A representative tissue factor mutant designated K165A, K166A TF is useful in a method for inhibiting thrombin-induced platelet aggregation in a mammal, either separately or in combination with a thrombolytic agent, an anticoagulant, or a GPIIbIIIa inhibitor.