摘要 |
Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: <IMAGE> Formula II wherein each of R1, R4, R5, R6 and R7 is independently selected from hydrido, lower alkyl, benzyl, and haloloweralkyl; wherein each of R2, R3 and R8 through R11 is independently selected from hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; wherein n is an integer of from four to six; wherein m is an integer of from two to four; wherein A is selected from phenyl, naphthyl, benzothienyl, benzofuranyl and thienyl; wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydrido, hydroxy, loweralkyl, loweralkoxy, halo, haloloweralkyl, amino, monoloweralkylamino and diloweralkylamino; or a pharmaceutically acceptable salt thereof.
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申请人 |
NATIONAL INSTITUTES OF HEALTH;BROWN UNIVERSITY |
发明人 |
BOWEN, WAYNE;DE COSTA, BRIAN R.;DOMINGUEZ, CELIA;HE, XIAO-SHU;RICE, KENNER C. |