摘要 |
A compound selected from the group consisting of a compound of the formula <IMAGE> I wherein A, B and E are individually selected from the group consisting of =CH- and =N- with at least one being =N-, R is selected from the group consisting of cycloalkyl of 3 to 6 carbon atoms, and alkenyl and alkynyl of 2 to 6 carbon atoms, R1 is hydrogen or alkyl of 1 to 3 carbon atoms, R2 and R3 together are -O-CH2-O- or are individually selected from the group consisting of hydrogen, halogen, -NO2, -CN, alkyl, alkylthio and alkoxy of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, -COR4, -(CH2)m -CX3, -O-(CH2)m-CX3, -S-(CH2)m-CX3, -O-(CX2)m-CX3 and -S-(CX2)m-CX3, R4 is hydrogen or alkyl or cycloalkyl of up to 6 carbon atoms, X is halogen and m is 0, 1, 2 or 3 and their addition salts with a non-toxic, pharmaceutically acceptable base having anti-flammatory and immulodulatory activity and their preparation.
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