| 摘要 |
PCT No. PCT/GB91/01693 Sec. 371 Date Jun. 3, 1992 Sec. 102(e) Date Jun. 3, 1992 PCT Filed Oct. 1, 1991 PCT Pub. No. WO92/06082 PCT Pub. Date Apr. 16, 1992.Disclosed herein are piperazine derivatives of the formula <IMAGE> (I) or a pharmaceutically acceptable acid addition salt thereof, wherein W is (CH2)m, CHOH or O, m is one of the integers 1 or 2, A is an alkylene chain of 1 to 3 carbon atoms optionally substituted by one or more (lower)alkyl groups, R is hydrogen or lower alkyl, R1 and R2 are each, independently, aryl or heteroaryl radicals with the proviso that R1 is not an optionally substituted indolyl radical, R3 is hydrogen or lower alkyl and R4 is an aryl or heteroaryl radical. The compounds are 5HT1A binding agents which may be used, for example, in the treatment of CNS disorders such as anxiety.
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