发明名称 |
Diaryläther-Heterozyklen. |
摘要 |
The invention concerns a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof, <CHEM> wherein Ar<1> is optionally substituted phenyl or naphthyl; X<1> is oxy, thio, sulphinyl or sulphonyl; Ar<2> is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms; R<1> is (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R<2> and R<3> together form a group of the formula -A<2>-X<2>-A<3>- wherein each of A<2> and A<3> is (1-4C)alkylene and X<2> is oxy, thio, sulphinyl, sulphonyl or imino. The invention also concerns processes for the manufacture of a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said heterocycle. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase. |
申请公布号 |
DE69011234(D1) |
申请公布日期 |
1994.09.08 |
申请号 |
DE1990611234 |
申请日期 |
1990.06.20 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC, LONDON, GB;ICI PHARMA, CERGY, FR |
发明人 |
EDWARDS, PHILIP NEIL, BRAMHALL, CHESHIRE, SK7 2NW, GB;BIRD, THOMAS GEOFFREY COLERICK, F-51420 WITRY-LES-REIMS, FR |
分类号 |
A61K31/35;A61K31/351;A61K31/38;A61K31/40;A61K31/44;A61K31/443;A61K31/50;A61K31/505;A61P29/00;A61P37/08;A61P43/00;C07D;C07D307/20;C07D309/10;C07D405/04;C07D405/12;C07D405/14;C07D409/12 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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