| 摘要 |
<p>PURPOSE:To obtain a new compound useful as a synthetic intermediate for a therapeutic agent for hyperlipemia such as compactin or mevinolin. CONSTITUTION:This compound is expressed by formula I (R1 is protecting group of OH selected from tetrahydropyranyl and acyl), e.g. (2aSR,5aRS,6RS,8 aSR,8bSR)-2a,3,5a,6,7,8,8a,8b-octahydro-3-oxo-6(tetrahydropyran-2-yl) oxy-2H- naphtho[1,8-be]furan-2-one. The compound expressed by formula I is obtained by subjecting a Z type olefin expressed by formula II (THP is tetrahydropyran-2- yl) to the basic cyclizing reaction in a solvent (e.g. THF). Since this compound expressed by formula I is capable of providing a compound keeping a state of the same steric configuration as that of compactin is obtained in introducing various substituent groups (R) into the 1-position of the naphthalene skeleton, the compound is convertible into an intermediate for synthesizing the compactin, etc., or its derivative.</p> |
