发明名称 |
HUMAN ANTI-TNF ANTIBODIES |
摘要 |
Human monoclonal antibodies (mAbs) which bind to human TNF.alpha.. Autoantibodies of both the IgM and IgG isotypes are disclosed. A preferred human monoclonal antibody is known as B5 (F78-1A10-B5 mAb) and it binds to recombinant human TNF.alpha. (rhTNF.alpha.) in ELISA format with a titer comparable to three high affinity neutralizing mouse mAbs. It also binds to cell surface TNF.alpha. and prevents TNF.alpha. secretion by human monocyte cell lines.
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申请公布号 |
CA2116888(A1) |
申请公布日期 |
1994.09.06 |
申请号 |
CA19942116888 |
申请日期 |
1994.03.03 |
申请人 |
MILES INC. |
发明人 |
BOYLE, PETRA;WETZEL, GAYLE D.;LEMBACH, KENNETH J. |
分类号 |
A61K39/395;A61K38/00;A61P43/00;C07K16/24;C12P21/08;(IPC1-7):C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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