发明名称 Oxepane isomers of rapamycin useful as immunosuppressive agents
摘要 A derivative of rapamycin of general formula (I) <IMAGE> I wherein R1 and R2 are selected from the group consisting of hydrogen, acyl, sulfonyl or alkyl or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.
申请公布号 US5344833(A) 申请公布日期 1994.09.06
申请号 US19930032910 申请日期 1993.03.18
申请人 AMERICAN HOME PRODUCTS CORPORATION 发明人 HUGHES, PHILIP F.
分类号 A61K31/435;A61K31/4353;A61K38/00;A61K39/00;A61K39/215;A61K39/295;A61P29/00;A61P31/12;A61P31/14;A61P37/06;C07D471/18;C07D498/18;C07K14/165;C07K16/08;C07K19/00;C12N15/09;C12Q1/68;(IPC1-7):A61K31/44 主分类号 A61K31/435
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