| 摘要 |
The invention concerns compounds of formula (I) yl, or alkynyl containing 1 to 6 carbon atoms; or an aromatic moiety selected from phenyl, naphthyl and 4-(phenylaza) phenyl wherein said aromatic group is optionally substituted by one or more substituents selected from C1-C6 alkyl, C1-C6 alkoxy, hydroxy, amino, mono- or di-(C1-C6)alkylamino, carboxy, (C1-C6 alkoxy)carbonyl, C2-C7 alkanoyl, (C1-C6) thioalkyl, halo, cyano, nitro, trifuluoromethyl, trifluoromethoxy or R1 is a heteroaromatic group of 5 to 10 ring atoms containing oxygen, nitrogen and/or sulfur as heteroatom(s) wherein said heteroaromatic group is optionally substituted by one or more substituents selected form C1-C6 alkyl, C1-C6 alkoxy, hydroxy, amino, mono- or di-(C1-C6)alkylamino, carboxy, (C1-C6 alkoxy)carbonyl, C2-C7 alkanoyl, (C1-C6) thioalkyl, halo, cyano, nitro, trifluoromethyl, trifluoromethoxy or R1 is NHCO2R2 wherein R2 is lower alkyl containing 1 to 6 carbon atoms; or a pharmaceutically acceptable salt thereof, which compounds are useful in the treatment of transplantation rejection, host versus graft disease, autoimmune diseases and diseases of inflammation. |
