POLYAMINE DERIVATIVES AS RADIOPROTECTIVE AGENTS

摘要

The present invention relates to polyamine derivatives of RHN-(CH2)m-NH-(CH2)n-NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C2-C6 alkyl or -(CH2)p-Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof which are useful as radioprotective agents. It relates also to the use of polyamines of the formula RHN-(CH2)m-NH-(CH2)n-NH-(CH2)m-NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C2-C6 alkyl or -(CH2)p-Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof as radioprotective agents.