发明名称 |
PREPARATION OF COLLOIDAL AQUEOUS SOLUTIONS OF ACTIVE SUBSTANCES OF LOW SOLUBILITY |
摘要 |
A process is disclosed for processing hardly soluble active substances together with phospholipids into a homogeneous solution. The process is characterized in that a) the active substance is mixed with a phospholipid, b) and acid aqueous solution of a carbohydrate is added to the residue at an increased temperature and the mixture is stirred at an increased temperature until a homogeneous colloidal solution is obtained, and c) this solution is cooled, set at a pH value from 4 to 5 and sterilized.
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申请公布号 |
CA2155085(A1) |
申请公布日期 |
1994.09.01 |
申请号 |
CA19942155085 |
申请日期 |
1994.02.07 |
申请人 |
KNOLL AKTIENGESELLSCHAFT |
发明人 |
ROSENBERG, JOERG;ROMERDHAL, CYNTHIA;HEBERGER, JUERGEN |
分类号 |
A61K47/16;A61K9/10;A61K47/24;A61K47/26;(IPC1-7):A61K47/24;A61K38/15;A61K31/275;A61K31/35;A61K31/47;A61K31/495 |
主分类号 |
A61K47/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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