发明名称 PREPARATION OF COLLOIDAL AQUEOUS SOLUTIONS OF ACTIVE SUBSTANCES OF LOW SOLUBILITY
摘要 A process is disclosed for processing hardly soluble active substances together with phospholipids into a homogeneous solution. The process is characterized in that a) the active substance is mixed with a phospholipid, b) and acid aqueous solution of a carbohydrate is added to the residue at an increased temperature and the mixture is stirred at an increased temperature until a homogeneous colloidal solution is obtained, and c) this solution is cooled, set at a pH value from 4 to 5 and sterilized.
申请公布号 CA2155085(A1) 申请公布日期 1994.09.01
申请号 CA19942155085 申请日期 1994.02.07
申请人 KNOLL AKTIENGESELLSCHAFT 发明人 ROSENBERG, JOERG;ROMERDHAL, CYNTHIA;HEBERGER, JUERGEN
分类号 A61K47/16;A61K9/10;A61K47/24;A61K47/26;(IPC1-7):A61K47/24;A61K38/15;A61K31/275;A61K31/35;A61K31/47;A61K31/495 主分类号 A61K47/16
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