CYCLIC BRADYKININ ANTAGONIST PEPTIDES

摘要

Cyclic compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acid substitutions are made at positions 2 and 5 or 6 to facilitate the cyclization of the peptide through covalent bonding of the amino acid side chains. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.