FLUORINATED 4-AMINOANDROSTADIENONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION

摘要

The present invention relates to compounds of formula (I) wherein (x) and (y) are single or double bonds; A is (1) or (2); R and R<3> are hydrogen or acyl; R<1> is hydrogen or fluorine; and wherein: when (y) is a single bond, R<2> is hydrogen, fluorine methyl, trifluoromethyl; when (y) is a double bond, R<2> is methylene provided that when one of (x) or (y) is a double bond the other is a single bond and at least one of R1 and R2 is fluorine or trifluoromethyl and the pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful as aromatase inhibitors.