PROCESS FOR PRODUCING LIPOSOME COMPOSITION

摘要

A process for producing a liposome composition which can inhibit the decomposition of the drugs contained therein, in particular, a physiologically active protein with a molecular weight of 500 to 100 thousand, has a high incorporation rate, can be administered subcutaneously or intramuscularly, and contributes to sustained release. The process comprises dissolving a lipid in a first organic solvent, preparing an emulsion by adding an aqueous drug solution to the lipid solution and emulsifying the resultant solution, mixing at a low temperature the emulsion with a second organic solvent wherein the lipid is sparingly soluble, recovering the precipitated fraction, and suspending the recovered fraction in an aqueous solvent.