发明名称 |
INHIBITION OF TAX-MEDIATED INCREASE IN DNA BINDING |
摘要 |
The Tax protein of Human T Cell Leukemia Virus Type 1 (HTLV-I) transcriptionally activates the HTLV-I promoter through binding sites for ATF, a family of cellular bZIP transcription factors. In this disclosure, it is reported that Tax dramatically increases the in vitro DNA binding activity of multiple ATF proteins. Tax also stimulates DNA binding of related bZIP proteins but does not affect the activity of proteins lacking a bZIP domain. The increased DNA binding activity occurs by a novel mechanism in which Tax promotes homodimerization in the absence of DNA. The elevated concentration of the bZIP homodimer results in increased DNA binding. |
申请公布号 |
WO9419494(A1) |
申请公布日期 |
1994.09.01 |
申请号 |
WO1994US01774 |
申请日期 |
1994.02.17 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
GREEN, MICHAEL, R.;WAGNER, SUZANNE |
分类号 |
C12N15/09;C07K14/15;C12N15/67;(IPC1-7):C12Q1/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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