| 发明名称 |
CYCLOBUTYL ANTISENSE OLIGONUCLEOTIDES, METHODS OF MAKING AND USE THEREOF |
| 摘要 |
Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics, therapeutics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed. |
| 申请公布号 |
WO9419023(A1) |
申请公布日期 |
1994.09.01 |
| 申请号 |
WO1993US01579 |
申请日期 |
1993.02.19 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK, PHILLIP, DAN;BASCHANG, GERHARD |
| 分类号 |
C07H21/02;A61K31/70;A61K38/00;A61P31/12;C07D473/00;C07D473/34;C07F7/18;C07F9/6561;C07H21/00;C07H21/04;C12N15/113;(IPC1-7):A61K48/00;C12Q1/68 |
主分类号 |
C07H21/02 |
| 代理机构 |
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代理人 |
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| 主权项 |
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