This invention provides pharmaceutical preparations containing highly concentrated tumor cytotoxic factor (TCF). The pharmaceutical prparations of the present invention contain highly concentrated TCF and a basic amino acid or their salts, or an organic or inorganic salt as a solubizer. The resultant compositions described in the present invention dissolve TCF at high concentrations of 10 mg/ml or over under about neutral and isotonic conditions. The resultant compositions are stable and are suitable for injection preparations.
申请公布号
EP0612530(A2)
申请公布日期
1994.08.31
申请号
EP19940301251
申请日期
1994.02.22
申请人
SNOW BRAND MILK PRODUCTS CO., LTD.
发明人
HAYASAKA, HITOSHI;KAWASHIMA, NOBUYUKI;UEDA, MASATSUGU;KUMAZAWA, EITARO, 59-1-4, GREEN TOWN