| 发明名称 |
Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 |
| 摘要 |
The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.
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| 申请公布号 |
US5342774(A) |
申请公布日期 |
1994.08.30 |
| 申请号 |
US19910807043 |
申请日期 |
1991.12.12 |
| 申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
BOON, THIERRY;VAN DER BRUGGEN, PIERRE;VAN DEN EYNDE, BENOIT;VAN PEL, ALINE;DE PLAEN, ETIENNE;LURQUIN, CHRISTOPHE;CHOMEZ, PATRICK;TRAVERSARI, CATIA |
| 分类号 |
A61K31/70;A61K9/127;A61K35/12;A61K35/14;A61K35/18;A61K38/00;A61K39/00;A61K39/395;A61K48/00;A61P35/00;C07K7/06;C07K14/00;C07K14/47;C07K14/52;C07K14/525;C07K14/54;C07K14/55;C07K14/705;C07K16/00;C07K16/30;C07K16/42;C07K17/00;C12N1/00;C12N1/20;C12N1/21;C12N5/10;C12N7/00;C12N15/00;C12N15/02;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12Q1/00;C12Q1/68;C12R1/19;G01N33/50;G01N33/53;G01N33/574;G01N33/577;G01N33/68;(IPC1-7):C12P21/02;C12P19/34;C12N5/00;C12N1/16;C12N1/18;C07K3/00;C07H15/12 |
主分类号 |
A61K31/70 |
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