Chrysospermins active peptides from apiocrea chrysosperma having a pharmacological effect,a process for their preparation and the use thereof

摘要

The invention relates to the peptide drugs chrysospermines of the formula I in which x and y denote, independently of one another, Aib or Iva, which are synthesised by the fungus Apiocrea chrysosperma during fermentation and accumulate in the culture broth, to a preparation process, to the use of the chrysospermines as pharmacological agents, in particular as agent against bacteria, fungi and/or nematodes and for the treatment of rejection reactions to organ transplants and of tumours, and to the microorganism Apiocrea chrysosperma DSM 7444.